Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | TGM2 | P21980 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20285821 | 0.96 | HTT (0.69) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL17532634 | 0.93 | LMNA (0.79) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL17532242 | 0.90 | LMNA (0.66) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL24038747 | 0.88 | LMNA (0.76) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL30189707 | 0.88 | HTT (0.68) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL759375 | 0.86 | LMNA (0.69) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL14288941 | 0.86 | LMNA (0.69) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL14288938 | 0.86 | LMNA (0.69) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL4654796 | 0.86 | LMNA (0.69) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL25030545 | 0.86 | LMNA (0.73) | LMNASMN1; SMN2HTTTGM2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355810-B1 | TREATMENT AND PREVENTION OF HYPERCHOLESTEROLEMIA, HYPERLIPIDEMIA, ATHEROSCLEROSIS | ADVANCED MEDICINE, INC. | 2002-03-12 | — | — | US | disclosed |