Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | BRD4 | O60885 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1156069 | 0.84 | BRD4 (0.63) | MDM2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL16008336 | 0.78 | BRD4 (0.72) | ALDH1A1MAPTGAASMN1; SMN2BRD4 | |
| SCHEMBL28985324 | 0.77 | TSHR (0.61) | ALDH1A1MAPTGAAHPGDRAB9A | |
| SCHEMBL1156780 | 0.74 | TSHR (0.49) | ALDH1A1MAPTRAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL7997890 | 0.74 | ALDH1A1 (0.56) | MDM2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL29551740 | 0.73 | ALDH1A1 (0.52) | MDM2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL375495 | 0.73 | BRD4 (0.58) | ALDH1A1MAPTRAB9ASMN1; SMN2BRD4 | |
| SCHEMBL12647490 | 0.72 | TSHR (0.53) | ALDH1A1MAPTGAAHPGDRAB9A | |
| SCHEMBL19727271 | 0.72 | TUBB4A (0.53) | MDM2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL16042329 | 0.72 | MAPT (0.57) | ALDH1A1MAPTRAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372777-B1 | ENZYME INHIBITORS TREATMENT OF INFLAMMATORY DISEASES AND OTHER DISEASES INVOLVING ELEVATED LEVELS OF CYTOKINES, AS WELL AS CENTRAL NERVOUS SYSTEM (CNS) DISORDERS, | ICOS CORPORATION | 2002-04-16 | — | — | US | disclosed |