Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547017 | 0.81 | DGAT1 (0.36) | ALDH1A1MAPK1USP2MAPTHPGD | |
| SCHEMBL3228869 | 0.81 | TSHR (0.46) | MAPK1HSD17B10 | |
| SCHEMBL6384724 | 0.79 | MAPK1 (0.32) | ALDH1A1MAPK1USP2MAPTHPGD | |
| SCHEMBL5503088 | 0.79 | USP2 (0.34) | ALDH1A1MAPK1USP2MAPTHPGD | |
| SCHEMBL5607319 | 0.77 | GAA (0.50) | ALDH1A1HSD17B10 | |
| SCHEMBL15131909 | 0.77 | MAPK1 (0.38) | ALDH1A1MAPK1USP2MAPTHPGD | |
| SCHEMBL8383005 | 0.76 | TDP1 (0.45) | ALDH1A1MAPK1USP2MAPTHPGD | |
| SCHEMBL11989018 | 0.75 | MGAM (0.32) | ALDH1A1MAPK1MAPT | |
| SCHEMBL11989017 | 0.75 | PAM (0.44) | MAPK1 | |
| SCHEMBL5606835 | 0.75 | LMNA (0.41) | ALDH1A1MAPK1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6359061-B1 | COMBINATORIAL LIBRARIES ARE USEFUL FOR SCREENING IN BIOLOGCAL ASSAYS IN ORDER TO IDENTIFY PHARMACEUTICALLY USEFUL COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6316623-B1 | USEFUL FOR SCREENING IN BIOLOGICAL ASSAYS IN ORDER TO IDENTIFY PHARMACEUTICALLY USEFUL COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2001-11-13 | — | — | US | disclosed |