Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | FDPS | P14324 | 2/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.52 |
| ▸ | TTR | P02766 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29711664 | 0.89 | FDPS (0.64) | NFE2L2KMT2AFDPSALDH1A1KDM4E | |
| SCHEMBL10075933 | 0.83 | FDPS (0.58) | NFE2L2KMT2AFDPSTTRALDH1A1 | |
| SCHEMBL8675291 | 0.83 | FDPS (0.61) | NFE2L2KMT2AFDPSALDH1A1KDM4E | |
| SCHEMBL29426332 | 0.83 | FDPS (0.61) | NFE2L2KMT2AFDPSALDH1A1KDM4E | |
| SCHEMBL11903912 | 0.81 | TTR (0.65) | NFE2L2KMT2AFDPSTTRALDH1A1 | |
| SCHEMBL1660732 | 0.81 | MET (0.57) | NFE2L2KMT2AFDPSTTRALDH1A1 | |
| SCHEMBL11903909 | 0.81 | TTR (0.65) | NFE2L2KMT2AFDPSTTRALDH1A1 | |
| SCHEMBL1660735 | 0.81 | MET (0.57) | NFE2L2KMT2AFDPSTTRALDH1A1 | |
| SCHEMBL1660737 | 0.81 | MET (0.57) | NFE2L2KMT2AFDPSTTRALDH1A1 | |
| SCHEMBL1660425 | 0.81 | TNFRSF1A (0.60) | NFE2L2KMT2AFDPSTTRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500823-B1 | ENERGY DEFICIENCY OF THE CELL CAUSED BY PARP INHIBITION, IN DIABETES COMPLICATIONS, IN OXYGEN DEFICIENT STATUS OF THE HEART AND BRAIN, IN NEURODEGENERATIVE DISEASES, IN THE TREATMENT OF AUTOIMMUNE AND/OR VIRAL DISEASES | N-GENE RESEARCH LABORATORIES, INC. | 2002-12-31 | — | — | US | claimed |
| CN-1211353-C | Unsaturated hydroximic acid derivatives as PARP inhibitors | GENE KUTAT KFT N (HU) | 2005-07-20 | — | — | CN | disclosed |