Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14455033 | 0.85 | PSEN1 (0.42) | PTGS2LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL30087228 | 0.85 | PSEN1 (0.42) | PTGS2LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL14455038 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL28600640 | 0.84 | ALDH1A1 (0.54) | PTGS2ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL23804143 | 0.83 | MCL1 (0.58) | LMNAALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL30087171 | 0.83 | LMNA (0.60) | PTGS2LMNAALDH1A1KDM4EMEN1 | |
| SCHEMBL30087260 | 0.82 | ALDH1A1 (0.56) | LMNAALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL7682529 | 0.82 | ALDH1A1 (0.61) | PTGS2ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL4697986 | 0.82 | ALDH1A1 (0.56) | LMNAALDH1A1TRIM24TYRTRIM33 | |
| SCHEMBL5577945 | 0.81 | SMN1; SMN2 (0.49) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500853-B1 | ENZYME INHIBITORS SUCH AS 4-((1-BENZHYDRYL-5-(((BUTYLAMINO)-CARBONYL)AMINO)-1H-INDOL-3-YL)METHYL)-3 -METHOXYBENZOIC ACID USED AS ANTIINFLAMMATORY AGENTS FOR PROPHYLAXIS OF ARTHRITIS, INFLAMMATORY BOWEL DISEASE OR ASTHMA | GENETICS INSTITUTE, LLC | 2002-12-31 | — | — | US | disclosed |
| EP-1062205-A2 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999043654-A2 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 1999-09-02 | — | — | WO | disclosed |