SCHEMBL7683292

SCHEMBL7683292

O=C(O)CC(NC(=O)OCc1ccccc1)C(=O)Cn1nnnc1Cc1c(Cl)cccc1Cl

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 17/20 0.58
CASP3 P42574 3/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7676848 0.94 CASP1 (0.54) CASP1CASP3
SCHEMBL7678223 0.93 CASP1 (0.54) CASP1CASP3
SCHEMBL7681972 0.93 CASP1 (0.51) CASP1CASP3
SCHEMBL7683677 0.92 CASP1 (0.50) CASP1CASP3
SCHEMBL7680016 0.91 CASP1 (0.48) CASP1CASP3
SCHEMBL7681991 0.90 CASP1 (0.53) CASP1
SCHEMBL7686569 0.90 CASP1 (0.47) CASP1CASP3
SCHEMBL7686221 0.89 CASP1 (0.48) CASP1CASP3
SCHEMBL7676922 0.89 CASP1 (0.50) CASP1CASP3
SCHEMBL7686951 0.89 CASP1 (0.46) CASP1CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6136834-A TETRAZOLE PEPTIDES ONO PHARMACEUTICAL CO., LTD. (JP) 2000-10-24 US claimed
EP-0900791-A1 TETRAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 1999-03-10 EP claimed
US-6376484-B1 FOR PREVENTION AND/OR TREATMENT OF VARIOUS KINDS OF INFLAMMATORY DISEASE ONO PHARMACEUTICAL CO., LTD. (JP) 2002-04-23 US disclosed
US-6136834-A TETRAZOLE PEPTIDES ONO PHARMACEUTICAL CO., LTD. (JP) 2000-10-24 US disclosed
EP-0900791-A1 TETRAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 1999-03-10 EP disclosed