Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 5/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665729 | 0.91 | ADRA1D (0.47) | ADRA1DADRA1AADRA1BMEN1KMT2A | |
| SCHEMBL7662035 | 0.90 | ADRA1D (0.42) | ADRA1DADRA1AADRA1BMEN1KMT2A | |
| SCHEMBL7932447 | 0.79 | GPBAR1 (0.56) | ADRA1DADRA1AADRA1BMEN1KMT2A | |
| SCHEMBL7924014 | 0.72 | GPBAR1 (0.55) | ADRA1DADRA1AADRA1BGPBAR1ALDH1A1 | |
| SCHEMBL6197304 | 0.67 | PDE1C (0.50) | ADRA1DADRA1AADRA1BPDE1C | |
| SCHEMBL7662361 | 0.66 | ADRA1A (0.58) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7664087 | 0.65 | ADRA1A (0.53) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7660010 | 0.65 | ADRA1A (0.53) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7665732 | 0.65 | ADRA1D (0.46) | ADRA1DADRA1AADRA1B | |
| SCHEMBL6196607 | 0.64 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339090-B1 | FOR THERAPY OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2002-01-15 | — | — | US | disclosed |
| WO-2000006565-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-02-10 | — | — | WO | disclosed |