SCHEMBL7684932

SCHEMBL7684932

Cc1nc(-c2ccc(-n3cc[nH]c3=O)cc2)cs1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 0.46
GAA P10253 3/20 0.46
KDM4E B2RXH2 2/20 0.46
POLB P06746 2/20 0.46
HTT P42858 2/20 0.46
TRIM24 O15164 1/20 0.45
ALDH1A1 P00352 5/20 0.44
HPGD P15428 3/20 0.44
MAPT P10636 2/20 0.44
RECQL P46063 2/20 0.44
ESR2 Q92731 1/20 0.44
NPC1 O15118 4/20 0.44
MMP12 P39900 1/20 0.44
PKM P14618 1/20 0.43
ROCK2 O75116 1/20 0.43
PIM1 P11309 1/20 0.43
GSK3B P49841 1/20 0.43
AURKB Q96GD4 1/20 0.43
TSHR P16473 2/20 0.42
LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7687127 0.80 ROCK2 (0.47) RAB9AGAAKDM4EPOLBHTT
SCHEMBL3858469 0.72 CMA1 (0.43) POLBHTTALDH1A1HPGDMAPT
SCHEMBL19626747 0.69 CDC25A (0.58) RAB9AGAAKDM4EPOLBHTT
SCHEMBL4666220 0.69 POLB (0.41) POLBALDH1A1HPGD
SCHEMBL2615402 0.69 GAA (0.65) RAB9AGAAKDM4EPOLBHTT
SCHEMBL7040245 0.68 RAB9A (0.59) RAB9AGAAKDM4EPOLBHTT
SCHEMBL13118689 0.68 ADRB1 (0.51) RAB9AGAAKDM4EPOLBHTT
SCHEMBL19627013 0.67 RAB9A (0.60) RAB9AGAAKDM4EPOLBHTT
Bromide SCHEMBL6832825 0.67 RAB9A (0.58) RAB9AGAAKDM4EPOLBHTT
SCHEMBL12203573 0.66 MAPT (0.58) RAB9AGAAKDM4EPOLBHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6362206-B1 FUNGICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-03-26 US disclosed
US-6034248-A FUNGICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-03-07 US disclosed