SCHEMBL7685669

SCHEMBL7685669

O=C1CC(=O)CC(c2cc(Cl)ccc2Cl)C1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 4/20 0.62
RECQL P46063 2/20 0.62
MAP1LC3B Q9GZQ8 1/20 0.42
MAPT P10636 4/20 0.41
GAA P10253 1/20 0.41
HTR1A P08908 1/20 0.39
ADRA1B P35368 1/20 0.39
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
ALOX15 P16050 1/20 0.38
TSHR P16473 1/20 0.38
CASP1 P29466 1/20 0.38
CYP2C19 P33261 1/20 0.38
SLC8B1 Q6J4K2 1/20 0.38
SLC9A1 P19634 1/20 0.38
CHRNB2 P17787 1/20 0.37
CHRNA4 P43681 1/20 0.37
POLB P06746 1/20 0.37
KMT2A Q03164 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5336238 0.85 TP53 (0.62) TP53RECQLMAP1LC3BMAPTGAA
SCHEMBL7683113 0.84 TP53 (0.51) TP53RECQLMAPTGAACYP1A2
SCHEMBL7687548 0.82 TP53 (0.50) TP53RECQLMAPTGAACHRNB2
SCHEMBL7689802 0.82 TP53 (0.59) TP53RECQLMAP1LC3BMAPTGAA
SCHEMBL6796450 0.82 TP53 (0.59) TP53RECQLMAPTGAAHTR1A
SCHEMBL14580256 0.80 MAP1LC3B (0.41) TP53RECQLMAP1LC3BMAPTHTR1A
SCHEMBL7685135 0.78 TP53 (0.46) TP53RECQLMAPTPOLBALDH1A1
SCHEMBL6797464 0.77 TP53 (1.00) TP53RECQLMAP1LC3BMAPTGAA
SCHEMBL9911450 0.76 TP53 (0.46) TP53GAAHTR1AADRA1BTSHR
SCHEMBL30997823 0.76 TP53 (0.46) TP53GAAHTR1AADRA1BTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6350749-B1 SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-02-26 US disclosed
EP-1057812-A1 AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF Takeda Chemical Industries, Ltd. (JP) 2000-12-06 EP disclosed
EP-0950418-A2 Composition for preventing or treating ischemic disease Takeda Chemical Industries, Ltd. (JP) 1999-10-20 EP disclosed
US-3947449-A Tetrahydroacridones having chemotherapeutic action and process for preparing them HOECHST AKTIENGESELLSCHAFT (DT) 1976-03-30 US disclosed