Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TYMP | P19971 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | DBH | P09172 | 1/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508654 | 0.84 | MEN1 (0.51) | CYP19A1CYP11B1CYP11B2MAPTTHRB | |
| SCHEMBL7670390 | 0.82 | ALDH1A1 (0.44) | TYMPDBHKCNH2LMNATLR8 | |
| SCHEMBL1126356 | 0.81 | HSD17B10 (0.51) | CYP11B1CYP11B2KCNH2LMNATLR8 | |
| SCHEMBL28617449 | 0.80 | GRM2 (0.52) | RAB9ACYP19A1CYP11B1CYP11B2MAPT | |
| SCHEMBL22309074 | 0.79 | RAB9A (0.46) | RAB9ACYP19A1CYP11B1CYP11B2MAPT | |
| SCHEMBL9836342 | 0.79 | RAB9A (0.48) | RAB9ACYP19A1CYP11B1CYP11B2MAPT | |
| SCHEMBL7499950 | 0.78 | LMNA (0.68) | MAPTLMNA | |
| SCHEMBL10642915 | 0.77 | RAB9A (0.47) | RAB9ACYP19A1CYP11B1CYP11B2MAPT | |
| SCHEMBL22310251 | 0.77 | RAB9A (0.48) | RAB9ACYP19A1CYP11B1CYP11B2MAPT | |
| SCHEMBL22309903 | 0.76 | RAB9A (0.49) | RAB9ACYP19A1CYP11B1CYP11B2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1131854-C | 1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives as tachykinin receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2003-12-24 | — | — | CN | disclosed |
| US-6346540-B1 | SUBSTANCE P ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM, PSYCHOLOGICAL AND BRAIN DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-02-12 | — | — | US | disclosed |
| EP-0855999-B1 | 1-(1,2-DISUBSTITUTED PIPERIDINYL)-4-SUBSTITUTED PIPERIDINE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2001-10-04 | — | — | EP | disclosed |
| US-6169097-B1 | 1-(1,2-Disubstituted piperidinyl)-4-substituted piperidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-01-02 | — | — | US | disclosed |
| CN-1206406-A | 1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives as tachykinin receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 1999-01-27 | — | — | CN | disclosed |
| EP-0855999-A1 | 1-(1,2-DISUBSTITUTED PIPERIDINYL)-4-SUBSTITUTED PIPERIDINE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-08-05 | — | — | EP | disclosed |
| WO-1997024324-A1 | 1-(1,2-DISUBSTITUTED PIPERIDINYL)-4-SUBSTITUTED PIPERIDINE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-07-10 | — | — | WO | disclosed |