SCHEMBL7686850

SCHEMBL7686850

COC(=O)Nc1ccc(C(=O)N(C)C)c(S(N)(=O)=O)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 2/20 0.43
CA1 P00915 4/20 0.41
CA2 P00918 4/20 0.41
CA9 Q16790 4/20 0.41
CA12 O43570 3/20 0.41
TUBB4A P04350 1/20 0.41
TUBB P07437 1/20 0.41
TUBA3C P0DPH7 1/20 0.41
TUBA1B P68363 1/20 0.41
TUBA4A P68366 1/20 0.41
TUBB4B P68371 1/20 0.41
TUBB3 Q13509 1/20 0.41
TUBB2A Q13885 1/20 0.41
TUBB8 Q3ZCM7 1/20 0.41
TUBA3E Q6PEY2 1/20 0.41
TUBA1A Q71U36 1/20 0.41
TUBA1C Q9BQE3 1/20 0.41
TUBB6 Q9BUF5 1/20 0.41
TUBB2B Q9BVA1 1/20 0.41
TUBB1 Q9H4B7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7637211 0.86 CA2 (0.50) CDK1CA1CA2CA9CA12
SCHEMBL7686634 0.83 CDK1 (0.46) CDK1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL7683635 0.83 CA1 (0.54) CA1CA2CA9CA12HTT
SCHEMBL7628690 0.80 CDK1 (0.54) CDK1CA1CA2CA9CA12
SCHEMBL7636571 0.78 KDM4E (0.49) CA1CA2CA9CA12HTT
SCHEMBL6104098 0.76 ALDH1A1 (0.42) CA1CA2CA9CA12SMN1; SMN2
SCHEMBL2977298 0.74 CDK1 (0.79) CDK1SMN1; SMN2MEN1KMT2AMAPT
SCHEMBL5847836 0.74 CDK1 (0.78) CDK1MEN1KMT2AMAPTGAA
SCHEMBL5847825 0.74 CDK1 (0.78) CDK1SMN1; SMN2MEN1KMT2AMAPT
SCHEMBL7924846 0.73 CA2 (0.43) CA1CA2CA9CA12SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6498253-B1 Acylated aminophenylsulfonylureas, processes for their preparation and their use as herbicides and plant growth regulators HOECHST SCHERING AGREVO GMBH (DE) 2002-12-24 US disclosed
CN-1066140-C Acylated aminophenylsulfonylureas, processes for their preparation and their use as herbicides and plant growth regulators HOECHST SCHERING AGREVO GMBH (DE) 2001-05-23 CN disclosed
US-5922646-A PRE-EMERGENCE AND POST-EMERGENCE HERBICIDES HOECHST SCHERING AGREVO GMBH (DE) 1999-07-13 US disclosed
EP-0757679-B1 ACYLATED AMINOPHENYLSULPHONYLUREAS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT-GROWTH REGULATORS HOECHST SCHERING AGREVO GMBH (DE) 1998-10-21 EP disclosed
EP-0757679-A1 ACYLATED AMINOPHENYLSULPHONYLUREAS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT-GROWTH REGULATORS Hoechst Schering AgrEvo GmbH (DE) 1997-02-12 EP disclosed
WO-1995029899-A1 ACYLATED AMINOPHENYLSULPHONYLUREAS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT-GROWTH REGULATORS HOECHST SCHERING AGREVO GMBH (DE) 1995-11-09 WO disclosed