Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1520716 | 0.80 | POLB (1.00) | POLBGAAMAPTHCAR2ALDH1A1 | |
| SCHEMBL1781122 | 0.73 | MAPT (0.57) | POLBGAAMAPTHCAR2ALDH1A1 | |
| SCHEMBL7687698 | 0.72 | ALDH1A1 (0.36) | POLBGAAMAPTALDH1A1KMT2A | |
| SCHEMBL4421957 | 0.72 | SMN1; SMN2 (0.56) | POLBGAAMAPTALDH1A1KMT2A | |
| SCHEMBL657849 | 0.72 | POLB (0.56) | POLBGAAMAPTHCAR2ALDH1A1 | |
| SCHEMBL7685181 | 0.71 | ALDH1A1 (0.36) | POLBGAAMAPTALDH1A1KMT2A | |
| SCHEMBL1781576 | 0.69 | POLB (0.56) | POLBGAAMAPTHCAR2ALDH1A1 | |
| SCHEMBL497608 | 0.69 | — | — | |
| SCHEMBL11471110 | 0.69 | MAPT (0.51) | POLBGAAMAPTHCAR2NOS3 | |
| SCHEMBL7686920 | 0.68 | LDHA (0.44) | POLBALDH1A1MAP1LC3BHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120214824-A1 | PROTEOSTASIS REGULATORS | PROTEOSTASIS THERAPEUTICS, INC. | 2012-08-23 | — | — | US | disclosed |
| US-20120214824-A1 | PROTEOSTASIS REGULATORS | PROTEOSTASIS THERAPEUTICS, INC. | 2012-08-23 | — | — | US | disclosed |
| WO-2012078902-A2 | PROTEOSTASIS REGULATORS | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2012-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214824-A1 | PROTEOSTASIS REGULATORS | PSMG3, HSPA5, HSP90B1 | POLB 2511/4885GAA 650/4885MAPT 357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.