Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 13/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046910 | 0.91 | CRHR1 (0.72) | CRHR1KMT2ASMN1; SMN2PKMTSHR | |
| SCHEMBL8047865 | 0.89 | CRHR1 (0.55) | CRHR1KMT2ASMN1; SMN2NAPEPLDPKM | |
| SCHEMBL7684973 | 0.81 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL7678178 | 0.79 | CRHR1 (0.57) | CRHR1KMT2ASMN1; SMN2PKMTSHR | |
| SCHEMBL9045095 | 0.79 | CRHR1 (0.59) | CRHR1KMT2ASMN1; SMN2NAPEPLDPKM | |
| SCHEMBL9047393 | 0.77 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL7683421 | 0.76 | CRHR1 (0.52) | CRHR1KMT2AHTT | |
| SCHEMBL7687345 | 0.74 | CRHR1 (0.63) | CRHR1KMT2ASMN1; SMN2PKMTSHR | |
| SCHEMBL9046520 | 0.73 | CRHR1 (0.50) | CRHR1KMT2A | |
| SCHEMBL7683371 | 0.73 | CRHR1 (0.58) | CRHR1KMT2ASMN1; SMN2PKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6342503-B1 | ANTIDEPRESSANTS, EATING DISORDERS | DUPONT PHARMACEUTICALS COMPANY | 2002-01-29 | — | — | US | disclosed |
| US-6107301-A | PSYCHOLOGICAL DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1995010506-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-04-20 | — | — | WO | disclosed |