Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 6/20 | 0.38 |
| ▸ | KDM1B | Q8NB78 | 3/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.35 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804449 | 0.85 | KDM1A (0.54) | KDM1AKDM1BCHRNB2CHRNA4 | |
| SCHEMBL31075168 | 0.84 | KDM1A (0.43) | HTR2AHTR2CHTR2BKDM1AKDM1B | |
| SCHEMBL7683113 | 0.81 | TP53 (0.51) | HTR2AHTR2CHTR2BCHRNB2CHRNA4 | |
| SCHEMBL31462794 | 0.73 | HTR2A (0.36) | HTR2AHTR2CHTR2BCHRNB2CHRNA4 | |
| SCHEMBL27295206 | 0.73 | OPRL1 (0.45) | HTR2AHTR2CHTR2BCHRNB2CHRNA4 | |
| SCHEMBL426443 | 0.72 | KDM1A (0.53) | KDM1AKDM1BCHRNB2CHRNA4 | |
| SCHEMBL31075301 | 0.68 | SLC9A1 (0.43) | HTR2AHTR2CHTR2BKDM1ACHRNB2 | |
| SCHEMBL7679054 | 0.67 | HTR2C (0.45) | HTR2AHTR2CHTR2B | |
| SCHEMBL22210215 | 0.67 | HTR2C (0.40) | HTR2AHTR2CHTR2BCHRNB2CHRNA4 | |
| SCHEMBL30415807 | 0.67 | VCAM1 (0.44) | TP53RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |
| EP-0950418-A2 | Composition for preventing or treating ischemic disease | Takeda Chemical Industries, Ltd. (JP) | 1999-10-20 | — | — | EP | disclosed |