Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 18/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9068400 | 0.92 | LSS (0.59) | LSSMEN1KMT2ASRD5A2 | |
| SCHEMBL21113955 | 0.85 | LSS (0.53) | LSSMEN1KMT2A | |
| SCHEMBL21114169 | 0.83 | LSS (0.52) | LSSMEN1KMT2ASRD5A2 | |
| SCHEMBL8478859 | 0.82 | LSS (0.52) | LSSMEN1KMT2A | |
| SCHEMBL7681910 | 0.82 | LSS (0.65) | LSSMEN1KMT2A | |
| SCHEMBL7681812 | 0.82 | LSS (0.64) | LSSMEN1KMT2ASRD5A2 | |
| SCHEMBL7677378 | 0.81 | LSS (0.70) | LSSMEN1KMT2A | |
| SCHEMBL8045180 | 0.81 | LSS (0.66) | LSSMEN1KMT2A | |
| SCHEMBL7681900 | 0.81 | LSS (1.00) | LSSMEN1KMT2A | |
| SCHEMBL8760010 | 0.81 | MAOB (0.57) | LSSMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190210973-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF CYSTIC FIBROSIS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2019-07-11 | — | — | US | disclosed |
| US-10143686-B2 | Oxidosqualene cyclase as a protein target for anticancer therapeutics | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2018-12-04 | — | — | US | disclosed |
| US-20140005187-A1 | OXIDOSQUALENE CYCLASE AS A PROTEIN TARGET FOR ANTICANCER THERAPEUTICS | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2014-01-02 | — | — | US | disclosed |
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| EP-0778264-B1 | Tertiary amines having antimycotic and cholesterol lowering activity | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| CN-1067991-C | Aminoalkyl subsetd. benzo-heterocyclic compounds | HOFFMANN LA ROCHE (CH) | 2001-07-04 | — | — | CN | disclosed |
| WO-2000076316-A1 | METHODS RELATED TO METABOLISM OF PARASITES AND MYCOBACTERIA | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2000-12-21 | — | — | WO | disclosed |
| US-6034275-A | FUGICIDES; ATICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-03-07 | — | — | US | disclosed |
| US-5856503-A | ANTICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1999-01-05 | — | — | US | disclosed |
| CN-1161328-A | Aminoalkyl subsetd. benzo-heterocyclic compounds | HOFFMANN LA ROCHE (CH) | 1997-10-08 | — | — | CN | disclosed |
| EP-0778271-A2 | Aminoalkyl-substituted benzo-heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | disclosed |
| EP-0778264-A1 | Tertiary amines having antimycotic and cholesterol lowering activity | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190210973-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF CYSTIC FIBROSIS | CFTR, SLC26A4, SERPINB1 | LSS 438/4885MEN1 3651/4885KMT2A 4674/4885 |
| US-20140005187-A1 | OXIDOSQUALENE CYCLASE AS A PROTEIN TARGET FOR ANTICANCER THERAPEUTICS | HMGCR, DHCR7, CYP46A1 | LSS 128/4885MEN1 2703/4885KMT2A 3327/4885 |
| US-10143686-B2 | Oxidosqualene cyclase as a protein target for anticancer therapeutics | COASY, HCCS, OSBP | LSS 26/4885MEN1 3695/4885KMT2A 3831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.