Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.63 |
| ▸ | DUSP3 | P51452 | 7/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.44 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.44 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL768622 | 0.86 | ALOX5 (0.48) | PTPN1DUSP3PTPN2TRPV1IP6K1 | |
| SCHEMBL2564471 | 0.85 | PTPN1 (0.61) | PTPN1DUSP3IP6K1IP6K3IP6K2 | |
| SCHEMBL1226204 | 0.83 | PTPN1 (0.58) | PTPN1DUSP3IP6K1IP6K3IP6K2 | |
| SCHEMBL766536 | 0.82 | TRPV1 (0.65) | TRPV1 | |
| SCHEMBL2564362 | 0.81 | PTPN1 (0.56) | PTPN1DUSP3IP6K1IP6K3IP6K2 | |
| SCHEMBL2568160 | 0.80 | PTPN1 (0.55) | PTPN1DUSP3IP6K1IP6K3IP6K2 | |
| SCHEMBL2568214 | 0.79 | PTPN1 (0.54) | PTPN1DUSP3TRPV1IP6K1IP6K3 | |
| SCHEMBL2567880 | 0.77 | PTPN1 (1.00) | PTPN1DUSP3IP6K1IP6K3IP6K2 | |
| SCHEMBL31526337 | 0.77 | PTGS1 (0.47) | PTPN1ALDH1A1PTGS1NOTUM | |
| SCHEMBL4076415 | 0.76 | PTPN1 (0.67) | PTPN1DUSP3IP6K1IP6K3IP6K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | TRPV1, TRPV5, TRPV3 | PTPN1 2000/4885DUSP3 2337/4885PTPN2 1852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.