Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 5/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.31 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.31 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2676320 | 0.91 | CCR1 (0.43) | CCR1CHRM2CCR5VNN1RIPK1 | |
| SCHEMBL7686534 | 0.86 | CCR1 (0.41) | CCR1CHRM2CCR5ALDH1A1SLC6A2 | |
| SCHEMBL7686360 | 0.84 | CCR1 (0.41) | CCR1CHRM2CCR5VNN1HTT | |
| SCHEMBL2676078 | 0.84 | CCR1 (0.36) | CCR1VNN1ALDH1A1SCN3ASLC6A2 | |
| SCHEMBL2675109 | 0.81 | CCR1 (0.38) | CCR1VNN1RIPK1ALDH1A1 | |
| SCHEMBL7688420 | 0.80 | CCR1 (0.51) | CCR1CHRM2CCR5VNN1RIPK1 | |
| SCHEMBL27608396 | 0.80 | CCR1 (0.51) | CCR1CHRM2CCR5VNN1RIPK1 | |
| SCHEMBL2676322 | 0.80 | CCR1 (0.60) | CCR1CHRM2CCR5RIPK1ALDH1A1 | |
| SCHEMBL4068181 | 0.79 | CCR1 (0.36) | CCR1VNN1RIPK1ALDH1A1 | |
| SCHEMBL7687929 | 0.78 | CCR1 (0.42) | CCR1CHRM2CCR5VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | disclosed |