SCHEMBL7686360

SCHEMBL7686360

CC(C)(O)CC[C@H](C[C@@H](O)[CH]Cc1cccc2ccccc12)C(N)=O

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 4/20 0.41
CHRM2 P08172 1/20 0.38
CCR5 P51681 1/20 0.38
ADA P00813 2/20 0.37
VNN1 O95497 1/20 0.36
MTNR1A P48039 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
METAP2 P50579 1/20 0.35
REN P00797 2/20 0.35
TDP1 Q9NUW8 1/20 0.35
HPGD P15428 1/20 0.34
HTT P42858 1/20 0.34
LMNA P02545 1/20 0.34
CTNNB1 P35222 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2675799 0.92 REN (0.35) CCR1ADAVNN1MTNR1AL3MBTL1
SCHEMBL7686534 0.84 CCR1 (0.41) CCR1CHRM2CCR5HTTLMNA
SCHEMBL2675801 0.80 CCR1 (0.47) CCR1CHRM2CCR5ADAMTNR1A
SCHEMBL7687929 0.80 CCR1 (0.42) CCR1CHRM2CCR5VNN1REN
SCHEMBL2676710 0.76 CCR1 (0.34) CCR1HTTLMNA
SCHEMBL27608396 0.76 CCR1 (0.51) CCR1CHRM2CCR5VNN1
SCHEMBL2676320 0.76 CCR1 (0.43) CCR1CHRM2CCR5VNN1
SCHEMBL7688420 0.76 CCR1 (0.51) CCR1CHRM2CCR5VNN1
SCHEMBL7688715 0.76 CCR1 (0.37) CCR1CHRM2CCR5L3MBTL1
SCHEMBL4064567 0.74 CYP2A6 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6403587-B1 AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND PFIZER INC. 2002-06-11 US disclosed