Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 5/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | FCER2 | P06734 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 2/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067308 | 0.92 | FCER2 (0.38) | CCR1CHRM2CCR5FCER2MMP9 | |
| SCHEMBL27608396 | 0.83 | CCR1 (0.51) | CCR1CHRM2CCR5VNN1 | |
| SCHEMBL7688420 | 0.83 | CCR1 (0.51) | CCR1CHRM2CCR5VNN1 | |
| SCHEMBL4068329 | 0.82 | FCER2 (0.43) | CCR1FCER2MMP9RENVNN1 | |
| SCHEMBL4067311 | 0.80 | CCR1 (0.48) | CCR1CHRM2CCR5FCER2MMP9 | |
| SCHEMBL7686360 | 0.80 | CCR1 (0.41) | CCR1CHRM2CCR5RENVNN1 | |
| SCHEMBL7688073 | 0.78 | CCR1 (0.51) | CCR1CHRM2CCR5VNN1 | |
| SCHEMBL7686534 | 0.78 | CCR1 (0.41) | CCR1CHRM2CCR5 | |
| SCHEMBL2675071 | 0.77 | CCR1 (0.40) | CCR1CHRM2CCR5EPHX1 | |
| SCHEMBL7688715 | 0.76 | CCR1 (0.37) | CCR1CHRM2CCR5CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | disclosed |