Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 5/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2676710 | 0.91 | CCR1 (0.34) | CCR1ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7688073 | 0.86 | CCR1 (0.51) | CCR1CHRM2CCR5ALDH1A1SLC6A2 | |
| SCHEMBL7686360 | 0.84 | CCR1 (0.41) | CCR1CHRM2CCR5LMNAHTT | |
| SCHEMBL2676711 | 0.80 | CCR1 (0.47) | CCR1CHRM2CCR5ALDH1A1SLC6A2 | |
| SCHEMBL2676320 | 0.78 | CCR1 (0.43) | CCR1CHRM2CCR5ALDH1A1SLC6A2 | |
| SCHEMBL7687929 | 0.78 | CCR1 (0.42) | CCR1CHRM2CCR5 | |
| SCHEMBL7688715 | 0.77 | CCR1 (0.37) | CCR1CHRM2CCR5ALDH1A1TSHR | |
| SCHEMBL2675799 | 0.76 | REN (0.35) | CCR1LMNAHTT | |
| SCHEMBL27608396 | 0.76 | CCR1 (0.51) | CCR1CHRM2CCR5 | |
| SCHEMBL7688420 | 0.76 | CCR1 (0.51) | CCR1CHRM2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | disclosed |