Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 20/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7688208 | 1.00 | LSS (0.76) | LSS | |
| SCHEMBL7688064 | 0.96 | LSS (0.74) | LSS | |
| Fumaric Acid SCHEMBL7684105 | 0.87 | LSS (0.68) | LSS | |
| Fumaric Acid SCHEMBL7684101 | 0.87 | LSS (0.68) | LSS | |
| SCHEMBL7681942 | 0.83 | LSS (0.64) | LSS | |
| SCHEMBL7681952 | 0.83 | LSS (0.64) | LSS | |
| SCHEMBL7687928 | 0.82 | LSS (1.00) | LSS | |
| Fumaric Acid SCHEMBL7681505 | 0.73 | LSS (0.80) | LSS | |
| Fumaric Acid SCHEMBL7681498 | 0.73 | LSS (0.80) | LSS | |
| SCHEMBL3365759 | 0.72 | LSS (0.64) | LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| US-6034275-A | FUGICIDES; ATICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-03-07 | — | — | US | disclosed |