Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 6/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.46 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.44 |
| ▸ | CCKAR | P32238 | 2/20 | 0.43 |
| ▸ | CCKBR | P32239 | 2/20 | 0.43 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7695356 | 0.87 | SLC16A3 (0.48) | KCNA5BCL2BCL2L1MCL1BCL2A1 | |
| SCHEMBL7706585 | 0.85 | ALDH1A1 (0.53) | PLATF2KAT6A | |
| SCHEMBL7694179 | 0.84 | AKR1C3 (0.48) | SLC16A3PLATF2KAT6A | |
| SCHEMBL7422050 | 0.80 | KCNA5 (0.49) | KCNA5KAT6A | |
| SCHEMBL7786988 | 0.80 | BCL2 (0.51) | KCNA5BCL2BCL2L1MCL1BCL2A1 | |
| SCHEMBL7786990 | 0.80 | BCL2 (0.51) | KCNA5BCL2BCL2L1MCL1BCL2A1 | |
| SCHEMBL7694857 | 0.80 | CA2 (0.43) | KCNA5CCKARCCKBRKAT6A | |
| SCHEMBL7791340 | 0.79 | CAPN1 (0.60) | KCNA5BCL2BCL2L1MCL1BCL2A1 | |
| SCHEMBL7384115 | 0.79 | CAPN1 (0.60) | KCNA5BCL2BCL2L1MCL1BCL2A1 | |
| SCHEMBL7703492 | 0.79 | CA2 (0.42) | CCKARCCKBRPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436925-B1 | BETTER ABLE TO CROSS MEMBRANES; INHIBITORS OF CYSTEINE PROTEASES LIKE CALPAIN I AND II AND CATHEPSIN B AND L, CAN THUS BE USED TO CONTROL DISEASES ASSOCIATED WITH AN ELEVATED ACTIVITY OF CALPAIN ENZYMES OR CATHEPSIN ENZYMES | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |