Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | CCKAR | P32238 | 1/20 | 0.39 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7702126 | 0.91 | PLAT (0.45) | CA2L3MBTL1PLATCCKARCCKBR | |
| SCHEMBL7698087 | 0.90 | CA2 (0.51) | CA2CTSLCTSBKMT2APIN1 | |
| SCHEMBL7706585 | 0.81 | ALDH1A1 (0.53) | CA2KMT2APLATCA1 | |
| SCHEMBL7694857 | 0.80 | CA2 (0.43) | CA2CAPN1CTSLCTSBPIN1 | |
| SCHEMBL7429916 | 0.79 | MAPK9 (0.41) | CA2CCKBRACE | |
| SCHEMBL7700700 | 0.79 | CA2 (0.52) | CA2CTSLCTSBKMT2AITGB1 | |
| SCHEMBL7688546 | 0.79 | KCNA5 (0.46) | PLATCCKARCCKBR | |
| SCHEMBL7421589 | 0.79 | PYGL (0.43) | CA2PLATCCKBRACE | |
| SCHEMBL7420454 | 0.78 | PYGL (0.33) | — | |
| SCHEMBL7690013 | 0.77 | CAPN1 (0.68) | CA2CAPN1CTSLCTSBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436925-B1 | BETTER ABLE TO CROSS MEMBRANES; INHIBITORS OF CYSTEINE PROTEASES LIKE CALPAIN I AND II AND CATHEPSIN B AND L, CAN THUS BE USED TO CONTROL DISEASES ASSOCIATED WITH AN ELEVATED ACTIVITY OF CALPAIN ENZYMES OR CATHEPSIN ENZYMES | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |