Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPR3 | P46089 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9589795 | 0.79 | HDAC6 (0.56) | HDAC6MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7263191 | 0.77 | NPC1 (0.53) | HDAC6MEN1KMT2ANPC1RAB9A | |
| SCHEMBL5001969 | 0.75 | L3MBTL1 (0.49) | HDAC6KMT2ACNR1ACHECNR2 | |
| SCHEMBL27497404 | 0.71 | MAPT (0.45) | MEN1KMT2ANPC1RAB9AAS3MT | |
| SCHEMBL9588430 | 0.69 | HDAC6 (0.51) | HDAC6MEN1KMT2AMAOBALDH1A1 | |
| SCHEMBL29366230 | 0.68 | TSHR (0.52) | HDAC6RAB9AMAOBALDH1A1KDM4E | |
| SCHEMBL756581 | 0.68 | TSHR (0.52) | HDAC6RAB9AMAOBALDH1A1KDM4E | |
| SCHEMBL12155468 | 0.68 | KDM4E (0.53) | HDAC6MEN1KMT2ANPC1RAB9A | |
| SCHEMBL1127799 | 0.66 | TSHR (0.50) | HDAC6RAB9AMAOBALDH1A1KDM4E | |
| SCHEMBL29366541 | 0.66 | TSHR (0.50) | HDAC6RAB9AMAOBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230218-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | AstraZeneca AB (SE) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001032622-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2001-05-10 | — | — | WO | disclosed |