SCHEMBL7689285

SCHEMBL7689285

Cc1ccc2c(Cl)cc(S(=O)(=O)NCc3ccccc3)c(O)c2n1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.51
LMNA P02545 2/20 0.49
SLC12A2 P55011 1/20 0.49
SLC12A5 Q9H2X9 1/20 0.49
GLA P06280 1/20 0.48
GAA P10253 1/20 0.47
MCL1 Q07820 3/20 0.47
KDM4E B2RXH2 2/20 0.46
CA12 O43570 2/20 0.42
CA9 Q16790 2/20 0.42
ACLY P53396 1/20 0.42
HTT P42858 2/20 0.42
PKM P14618 1/20 0.42
VCAM1 P19320 1/20 0.42
ALDH1A1 P00352 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
POLB P06746 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
ATM Q13315 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7691447 0.91 MAPT (0.51) MAPTLMNAMCL1KDM4EACLY
SCHEMBL7690128 0.90 MCL1 (0.52) MAPTLMNASLC12A2SLC12A5GAA
SCHEMBL8311550 0.89 MAPT (0.49) MAPTGAAACLYHTTALDH1A1
SCHEMBL7691423 0.87 TDP1 (0.50) MAPTGAAKDM4EACLYHTT
SCHEMBL7686834 0.86 ALDH1A1 (0.52) MAPTGAAKDM4EACLYHTT
SCHEMBL7692330 0.86 MAPT (0.48) MAPTMCL1ACLYL3MBTL1
SCHEMBL7691523 0.85 SMN1; SMN2 (0.55) GAAKDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL7787448 0.83 KDM4E (0.64) MAPTLMNASLC12A2SLC12A5GLA
SCHEMBL7686867 0.82 MAPT (0.46) MAPTLMNAGAAKDM4EHTT
SCHEMBL7685938 0.82 MAPT (0.46) MAPTLMNAGAAKDM4EACLY

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6211376-B1 HERPES VIRUS, CYTOMEGALO VIRUS, VARICELLA-ZOSTER VIRUS,EPSTEIN-BARR VIRUS PHARMACIA & UPJOHN COMPANY 2001-04-03 US claimed
EP-0927164-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1999-07-07 EP claimed
WO-1998011073-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1998-03-19 WO claimed
US-6500842-B1 N-((4-CHLOROPHENYL)METHYL)-8-HYDROXY-7-QUINOLINECARBOXAMIDE ADMINISTERED AS VIRICIDES AGAINST HERPES VIRUS PHARMACIA & UPJOHN COMPANY 2002-12-31 US disclosed
US-6310211-B1 ANTI-VIRAL ACTIVITY AGAINST HERPES VIRUS, CYTOMEGALOVIRUS. MANY OF THESE COMPOUNDS ARE ALSO ACTIVE AGAINST VARICELLA ZOSTER VIRUS, EPSTEIN-BARR VIRUS, HERPES SIMPLEX VIRUS AND HUMAN HERPES VIRUS TYPE 8 PHARMACIA & UPJOHN COMPANY 2001-10-30 US disclosed
US-6252080-B1 HERPES, CYTOMEGALO VIRUS PHARMACIA & UPJOHN COMPANY 2001-06-26 US disclosed
US-6211376-B1 HERPES VIRUS, CYTOMEGALO VIRUS, VARICELLA-ZOSTER VIRUS,EPSTEIN-BARR VIRUS PHARMACIA & UPJOHN COMPANY 2001-04-03 US disclosed
EP-0927164-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1999-07-07 EP disclosed
WO-1998011073-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1998-03-19 WO disclosed