Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.61 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.61 |
| ▸ | CLK2 | P49760 | 1/20 | 0.61 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.61 |
| ▸ | GSK3B | P49841 | 6/20 | 0.44 |
| ▸ | GSK3A | P49840 | 5/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.44 |
| ▸ | CDK1 | P06493 | 4/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7690467 | 0.91 | CSNK1A1 (0.60) | CSNK1A1CSNK1DCLK2CSNK1G1GSK3B | |
| SCHEMBL7682924 | 0.85 | CSNK1A1 (0.64) | CSNK1A1CSNK1DCLK2CSNK1G1GSK3B | |
| SCHEMBL7691089 | 0.85 | GCGR (0.48) | CSNK1A1CSNK1DCLK2CSNK1G1GSK3B | |
| SCHEMBL7689216 | 0.82 | CSNK1A1 (0.64) | CSNK1A1CSNK1DCLK2CSNK1G1GSK3B | |
| SCHEMBL7682958 | 0.78 | CSNK1A1 (0.59) | CSNK1A1CSNK1DCLK2CSNK1G1GSK3B | |
| SCHEMBL7687974 | 0.78 | GCGR (0.49) | CSNK1A1CSNK1DCLK2CSNK1G1CDK5 | |
| SCHEMBL7685369 | 0.77 | CSNK1A1 (1.00) | CSNK1A1CSNK1DCLK2CSNK1G1CDK2 | |
| SCHEMBL7689430 | 0.74 | CSNK1A1 (0.61) | CSNK1A1CSNK1DCLK2CSNK1G1GSK3B | |
| Hydrochloric Acid SCHEMBL7742023 | 0.74 | CSNK1A1 (0.93) | CSNK1A1CSNK1DCLK2CSNK1G1CDK2 | |
| SCHEMBL7690506 | 0.74 | CSNK1A1 (0.61) | CSNK1A1CSNK1DCLK2CSNK1G1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417202-B1 | 3-ACETYL-4-METHYL-2,5-DI(4-PYRIDYL)-1H-PYRROLE, FOR EXAMPLE; TREATING CELL ADHESION MOLECULES (CAMS) MEDIATED DISEASES SUCH AS ARTHRITIS, AIDS, SEPTIC SHOCK, CACHEXIA, TRANSPLANT REJECTION | PFIZER INC. | 2002-07-09 | — | — | US | disclosed |
| US-20020049235-A1 | 3-acetyl-4-methyl-2,5-di(4-pyridyl)-1H-pyrrole, for example; treating cell adhesion molecules (CAMs) mediated diseases such as arthritis, AIDS, septic shock, cachexia, transplant rejection | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049235-A1 | 3-acetyl-4-methyl-2,5-di(4-pyridyl)-1H-pyrrole, for example; treating cell adhesion molecules (CAMs) mediated diseases such as arthritis, AIDS, septic shock, cachexia, transplant rejection | ICAM1, VCAM1, CD14 | CSNK1A1 2321/4885CSNK1D 2460/4885CLK2 4121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.