Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 5/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6693880 | 0.85 | MMP1 (0.57) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL6693912 | 0.77 | MMP13 (0.50) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL6690306 | 0.75 | MMP1 (0.45) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL6691917 | 0.73 | MMP1 (0.43) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL6690999 | 0.73 | MMP13 (0.58) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL6691935 | 0.71 | MMP13 (0.60) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL6693885 | 0.70 | MMP13 (0.36) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL6694370 | 0.70 | MMP13 (0.54) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL7672124 | 0.69 | MMP13 (0.77) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL6691597 | 0.69 | MMP13 (0.77) | MMP2MMP13MMP1MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458822-B2 | (4R)-1-(4-(4-FLUOROPHENOXY)BENZYL)-2-OXO-IMIDAZOLIDINE-4 -CARBOXYLIC ACID HYDROXYAMIDE, FOR EXAMPLE; TREATING VARIOUS DISEASES INCLUDING OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, CANCER, OSTEOPOROSIS, STROKES | PFIZER INC. | 2002-10-01 | — | — | US | claimed |