Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7254356 | 0.99 | ALDH1A1 (0.42) | ALDH1A1KDM4ESMN1; SMN2HTR7HTR1B | |
| SCHEMBL7690574 | 0.88 | HTR7 (0.42) | ALDH1A1KDM4ESMN1; SMN2HTR7HTR1B | |
| Hydrochloric Acid SCHEMBL7254351 | 0.87 | HTR7 (0.41) | ALDH1A1KDM4ESMN1; SMN2HTR7HTR1B | |
| SCHEMBL7126917 | 0.86 | LMNA (0.38) | — | |
| SCHEMBL7127448 | 0.86 | MEN1 (0.34) | ALDH1A1KDM4EHTR7DRD2HTR6 | |
| SCHEMBL7135194 | 0.86 | TP53 (0.37) | KDM4ESMN1; SMN2HTR7HTR1BHTR6 | |
| SCHEMBL7131752 | 0.86 | ALDH1A1 (0.39) | ALDH1A1HTR7 | |
| Hydrochloric Acid SCHEMBL7158439 | 0.85 | TP53 (0.39) | KDM4ESMN1; SMN2HTR7HTR1BHTR6 | |
| SCHEMBL7131947 | 0.84 | ALDH1A1 (0.44) | ALDH1A1KDM4ESMN1; SMN2HTR7HTR1B | |
| SCHEMBL7129112 | 0.82 | PTGDR2 (0.44) | ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420391-B1 | PREVENTION AND/OR TREATMENT OF VARIOUS INFLAMMATORY DISEASES, SEPSIS, MULTIPLE MYELOMA, PLASMA CELL LEUKEMIA, OSTEOPOROSIS, CACHEXIA, PSORIASIS, NEPHRITIS, RENAL CELL CARCINOMA, KAPOSI'S SARCOMA, RHEUMATOID ARTHRITIS, GAMMOPATHY, CASTLEMAN'S | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1067128-A1 | FUSED THIOPHENE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-10 | — | — | EP | claimed |