Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 7/20 | 0.60 |
| ▸ | MMP13 | P45452 | 7/20 | 0.60 |
| ▸ | MMP9 | P14780 | 6/20 | 0.60 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934149 | 0.90 | MMP9 (0.75) | MMP1MMP13MMP9ADAM17ALDH1A1 | |
| SCHEMBL6934097 | 0.81 | MMP9 (0.75) | MMP1MMP13MMP9ADAM17ALDH1A1 | |
| SCHEMBL6935134 | 0.79 | MMP9 (0.80) | MMP1MMP13MMP9ADAM17ALDH1A1 | |
| SCHEMBL6932184 | 0.76 | MMP1 (0.62) | MMP1MMP13MMP9ADAM17ALDH1A1 | |
| SCHEMBL6930637 | 0.75 | MMP9 (1.00) | MMP1MMP13MMP9ADAM17NAMPT | |
| SCHEMBL6935154 | 0.75 | MMP9 (0.77) | MMP1MMP13MMP9ADAM17ALDH1A1 | |
| SCHEMBL7347181 | 0.75 | MMP9 (0.75) | MMP1MMP13MMP9ADAM17ALDH1A1 | |
| SCHEMBL5861404 | 0.75 | ALDH1A1 (0.50) | ALDH1A1MAPK1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL6929858 | 0.73 | MMP1 (0.56) | MMP1MMP13MMP9ADAM17ALDH1A1 | |
| SCHEMBL5860273 | 0.73 | CYP1A2 (0.54) | ALDH1A1MAPK1SMN1; SMN2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6342508-B1 | ENZYME INHIBITORS FOR PROTECTION OF CONNECTIVE TISSUES | AMERICAN CYANAMID COMPANY | 2002-01-29 | — | — | US | disclosed |