Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 9/20 | 0.97 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 0.97 |
| ▸ | HTR1A | P08908 | 2/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.97 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.97 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.97 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.97 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.97 |
| ▸ | HTR2B | P41595 | 1/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.95 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.95 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.95 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alprenolol SCHEMBL34637 | 0.99 | ADRB2 (1.00) | ADRB2ADRB1LMNAHTR1ASLC6A4 | |
| Alprenolol SCHEMBL29414120 | 0.99 | ADRB2 (1.00) | ADRB2ADRB1LMNAHTR1ASLC6A4 | |
| Alprenolol SCHEMBL4538381 | 0.99 | ADRB2 (1.00) | ADRB2ADRB1LMNAHTR1ASLC6A4 | |
| Alprenolol SCHEMBL6508231 | 0.99 | ADRB2 (1.00) | ADRB2ADRB1LMNAHTR1ASLC6A4 | |
| Alprenolol SCHEMBL34636 | 0.99 | ADRB2 (1.00) | ADRB2ADRB1LMNAHTR1ASLC6A4 | |
| Alprenolol SCHEMBL29355107 | 0.99 | ADRB2 (1.00) | ADRB2ADRB1LMNAHTR1ASLC6A4 | |
| Alprenolol SCHEMBL349102 | 0.97 | LMNA (1.00) | ADRB2ADRB1LMNAHTR1ASLC6A4 | |
| Alprenolol SCHEMBL10762606 | 0.97 | ADRB2 (0.97) | ADRB2ADRB1LMNAHTR1ASLC6A4 | |
| Alprenolol SCHEMBL29725600 | 0.97 | LMNA (1.00) | ADRB2ADRB1LMNAHTR1ASLC6A4 | |
| Alprenolol SCHEMBL349100 | 0.97 | LMNA (1.00) | ADRB2ADRB1LMNAHTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6335176-B1 | REAGENT IS SUCCINIMIDYL MOIETY LINKED TO KINASE SUBSTRATE; CAN BE LINKED TO FREE PRIMARY OR SECONDARY AMINE IN COMPOUND TO BE PHOSPHORYLATED | PHARMACOPEIA, INC. | 2002-01-01 | — | — | US | disclosed |