Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPEP | Q07075 | 6/20 | 0.39 |
| ▸ | ANPEP | P15144 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
| ▸ | GRM8 | O00222 | 1/20 | 0.30 |
| ▸ | GRM6 | O15303 | 1/20 | 0.30 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | GSR | P00390 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.30 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.30 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.30 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.30 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.30 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.30 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.30 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10415301 | 0.93 | ANPEP (0.35) | ENPEPANPEPPTGS1SLC7A11 | |
| SCHEMBL936368 | 0.85 | ENPEP (0.41) | ENPEPANPEPPTGS1SLC7A11FOLH1 | |
| SCHEMBL28302949 | 0.85 | ENPEP (0.41) | ENPEPANPEPPTGS1SLC7A11FOLH1 | |
| SCHEMBL9621381 | 0.83 | PTGS1 (0.50) | ENPEPANPEPPTGS1SLC7A11GRIK1 | |
| SCHEMBL7730862 | 0.81 | ANPEP (0.33) | ENPEPANPEPPTGS1SLC7A11 | |
| SCHEMBL5988945 | 0.79 | PTGS1 (0.44) | ENPEPANPEPPTGS1SLC7A11 | |
| SCHEMBL7147125 | 0.79 | — | — | |
| SCHEMBL7147126 | 0.79 | — | — | |
| SCHEMBL4439365 | 0.78 | ANPEP (0.36) | ENPEPANPEPPTGS1SLC7A11 | |
| SCHEMBL20897398 | 0.77 | GRIK1 (0.31) | PTGS1SLC7A11GSRGRIK1GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4383994-A | Homocysteine thiolactone salts and use thereof as anti-neoplastic agents | MCCULLY KILMER S | 1983-05-17 | — | — | US | claimed |
| WO-2001000609-A9 | METHOD FOR SYNTHESIS OF N-HOMOCYSTEINE THIOLACTONYL RETINAMIDE | UNIV BAYLOR (US) | 2002-07-25 | — | — | WO | disclosed |
| US-6287818-B1 | CONJUGATING, IN SINGLE REACTION MIXTURE, RETINOIC ACID WITH HOMOCYSTEINE THIOLACTONE TO FORM N-HOMOCYSTEINE THIOLACTONYL RETINAMIDE, THEN MIXING WITH 5'-DEOXYADENOSINE COBALAMIN; HIGH PURITY AND YIELD; ANTICANCER AGENTS WITH REDUCED TOXICITY | BAYLOR UNIVERSITY | 2001-09-11 | — | — | US | disclosed |
| US-6274742-B1 | REACTING RETINOIC ACID WITH HOMOCYSTEINE THIOLACTONE | BAYLOR UNIVERSITY | 2001-08-14 | — | — | US | disclosed |
| WO-2001000609-A1 | METHOD FOR SYNTHESIS OF N-HOMOCYSTEINE THIOLACTONYL RETINAMIDE | BAYLOR UNIVERSITY (US) | 2001-01-04 | — | — | WO | disclosed |
| US-6054595-A | REACTING RETINOIC ACID WITH HOMOCYSTEINE THIOLACTONE | BAYLOR UNIVERSITY (US) | 2000-04-25 | — | — | US | disclosed |
| US-4925931-A | N-homocysteine thiolactonyl retinamido cobalamin and methods of use thereof | MCCULLY KILMER S (US) | 1990-05-15 | — | — | US | disclosed |
| US-4383994-A | Homocysteine thiolactone salts and use thereof as anti-neoplastic agents | MCCULLY KILMER S | 1983-05-17 | — | — | US | disclosed |
| US-4383994-A | Homocysteine thiolactone salts and use thereof as anti-neoplastic agents | MCCULLY KILMER S | 1983-05-17 | — | — | US | disclosed |