Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7160026 | 0.99 | KMT2A (0.45) | KMT2AMEN1KDM4EALDH1A1HTT | |
| SCHEMBL7133441 | 0.94 | KMT2A (0.44) | KMT2AMEN1KDM4EALDH1A1HTT | |
| SCHEMBL7693051 | 0.90 | KMT2A (0.46) | KMT2AMEN1KDM4EALDH1A1HTT | |
| SCHEMBL7133168 | 0.89 | KDM4E (0.49) | KMT2AMEN1KDM4EALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL7160031 | 0.89 | KMT2A (0.45) | KMT2AMEN1KDM4EALDH1A1HTT | |
| SCHEMBL7126147 | 0.88 | APLNR (0.47) | KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL7129579 | 0.87 | SMN1; SMN2 (0.43) | KMT2AMEN1KDM4EALDH1A1HTT | |
| SCHEMBL7132604 | 0.87 | CA1 (0.37) | ALDH1A1HTTSMN1; SMN2PKMCA1 | |
| SCHEMBL7164367 | 0.86 | RAB9A (0.42) | KMT2AMEN1KDM4EALDH1A1HTT | |
| SCHEMBL7696310 | 0.86 | SMN1; SMN2 (0.43) | KMT2AMEN1KDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420391-B1 | PREVENTION AND/OR TREATMENT OF VARIOUS INFLAMMATORY DISEASES, SEPSIS, MULTIPLE MYELOMA, PLASMA CELL LEUKEMIA, OSTEOPOROSIS, CACHEXIA, PSORIASIS, NEPHRITIS, RENAL CELL CARCINOMA, KAPOSI'S SARCOMA, RHEUMATOID ARTHRITIS, GAMMOPATHY, CASTLEMAN'S | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1067128-A1 | FUSED THIOPHENE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-10 | — | — | EP | claimed |