SCHEMBL7693379

SCHEMBL7693379

CC(C)(C)OC(=O)C(Cc1ccc(O)cc1)Nc1nnc(N)s1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LY96 Q9Y6Y9 1/20 0.48
CTSS P25774 1/20 0.43
CTSK P43235 1/20 0.43
ITGA4 P13612 2/20 0.40
ITGB7 P26010 2/20 0.40
ESR1 P03372 1/20 0.40
ESR2 Q92731 1/20 0.40
NPR3 P17342 2/20 0.39
LNPEP Q9UIQ6 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C8 P10632 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
POLB P06746 1/20 0.38
MAPT P10636 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
ELANE P08246 1/20 0.37
MDM4 O15151 1/20 0.36
MDM2 Q00987 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7693381 1.00 LY96 (0.48) LY96CTSSCTSKITGA4ITGB7
SCHEMBL7692142 0.79 NPSR1 (0.42) NPR3CYP3A4CYP2C8CYP2C9CYP2C19
SCHEMBL7691052 0.79 HTT (0.38) NPR3POLBMAPTTDP1
SCHEMBL7685067 0.78 MMP1 (0.48) CYP2C9CYP2C19POLB
SCHEMBL7689863 0.78 MMP1 (0.48) CYP2C9CYP2C19POLB
SCHEMBL6286907 0.78 ELANE (0.46) LY96ITGA4ITGB7NPR3CYP3A4
SCHEMBL7693656 0.76 CTSS (0.38) CTSSCTSKPOLB
SCHEMBL7684474 0.76 TACR1 (0.50) CTSSCTSKPOLBMAPTTDP1
SCHEMBL7684472 0.76 TACR1 (0.50) CTSSCTSKPOLBMAPTTDP1
SCHEMBL19354815 0.75 CTSS (0.53) LY96CTSSCTSKITGA4ITGB7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6500842-B1 N-((4-CHLOROPHENYL)METHYL)-8-HYDROXY-7-QUINOLINECARBOXAMIDE ADMINISTERED AS VIRICIDES AGAINST HERPES VIRUS PHARMACIA & UPJOHN COMPANY 2002-12-31 US disclosed
US-6310211-B1 ANTI-VIRAL ACTIVITY AGAINST HERPES VIRUS, CYTOMEGALOVIRUS. MANY OF THESE COMPOUNDS ARE ALSO ACTIVE AGAINST VARICELLA ZOSTER VIRUS, EPSTEIN-BARR VIRUS, HERPES SIMPLEX VIRUS AND HUMAN HERPES VIRUS TYPE 8 PHARMACIA & UPJOHN COMPANY 2001-10-30 US disclosed
US-6252080-B1 HERPES, CYTOMEGALO VIRUS PHARMACIA & UPJOHN COMPANY 2001-06-26 US disclosed
US-6211376-B1 HERPES VIRUS, CYTOMEGALO VIRUS, VARICELLA-ZOSTER VIRUS,EPSTEIN-BARR VIRUS PHARMACIA & UPJOHN COMPANY 2001-04-03 US disclosed
EP-0927164-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1999-07-07 EP disclosed
WO-1998011073-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1998-03-19 WO disclosed