Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD4 | P21917 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL768843 | 0.90 | HRH3 (0.34) | DRD2DRD4DRD3ACHEHRH3 | |
| SCHEMBL380695 | 0.87 | CHRM3 (0.45) | CHRM3 | |
| SCHEMBL769390 | 0.86 | TRPV4 (0.36) | GPR119SIRT5DRD2DRD4DRD3 | |
| SCHEMBL768562 | 0.85 | MCHR1 (0.41) | GPR119SIRT5DRD2DRD3TRPV4 | |
| SCHEMBL769174 | 0.84 | MCHR1 (0.41) | GPR119SIRT5DRD2DRD3TRPV4 | |
| SCHEMBL768695 | 0.83 | DRD2 (0.39) | SIRT5DRD2DRD4DRD3KCNH2 | |
| SCHEMBL768056 | 0.83 | SLC2A1 (0.36) | DRD2DRD3TRPV4ACHEADRB2 | |
| SCHEMBL768421 | 0.83 | OPRM1 (0.35) | SIRT5 | |
| SCHEMBL768428 | 0.82 | MCHR1 (0.36) | GPR119SIRT5DRD2TRPV4ADRB2 | |
| SCHEMBL768307 | 0.82 | MCHR1 (0.42) | GPR119DRD2TRPV4ACHEADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071467-A1 | AMIDE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071467-A1 | AMIDE DERIVATIVE | CHRM3, CHRM2, TACR2 | GPR119 354/4885SIRT5 674/4885DRD2 294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.