Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 6/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009651 | 0.86 | EPHX1 (0.40) | NAAASMN1; SMN2RAB9AEPHX1NPC1 | |
| SCHEMBL30965549 | 0.81 | ACHE (0.39) | SMN1; SMN2RAB9AEPHX1NPC1MAPT | |
| SCHEMBL6313168 | 0.80 | EPHX1 (0.37) | SMN1; SMN2RAB9AEPHX1NPC1MAPT | |
| SCHEMBL3390391 | 0.78 | SMN1; SMN2 (0.36) | NAAASMN1; SMN2RAB9AEPHX1NPC1 | |
| SCHEMBL3390388 | 0.78 | SMN1; SMN2 (0.36) | NAAASMN1; SMN2RAB9AEPHX1NPC1 | |
| SCHEMBL30135867 | 0.78 | EPHX1 (0.38) | SMN1; SMN2RAB9AEPHX1NPC1MAPT | |
| SCHEMBL4629906 | 0.78 | EPHX1 (0.38) | NAAASMN1; SMN2RAB9AEPHX1NPC1 | |
| SCHEMBL1383077 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9AEPHX1NPC1MAPT | |
| SCHEMBL7841197 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9AEPHX1NPC1MAPT | |
| SCHEMBL3010245 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9AEPHX1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002079190-A1 | 3-SUBSTITUTED INDOLES AS CHEMOKINE ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-10-10 | — | — | WO | disclosed |