Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 7/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NAAA | Q02083 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3390391 | 1.00 | SMN1; SMN2 (0.36) | SMN1; SMN2NPC1RAB9AMAPTTP53 | |
| SCHEMBL6313168 | 0.88 | EPHX1 (0.37) | SMN1; SMN2NPC1RAB9AMAPTTP53 | |
| SCHEMBL7009651 | 0.83 | EPHX1 (0.40) | SMN1; SMN2NPC1RAB9AMAPTTP53 | |
| SCHEMBL7694341 | 0.78 | NAAA (0.37) | SMN1; SMN2NPC1RAB9AMAPTTP53 | |
| SCHEMBL30965549 | 0.78 | ACHE (0.39) | SMN1; SMN2NPC1RAB9AMAPTTP53 | |
| SCHEMBL6167490 | 0.77 | SMN1; SMN2 (0.36) | SMN1; SMN2NPC1RAB9AMAPTTP53 | |
| SCHEMBL6167492 | 0.77 | SMN1; SMN2 (0.36) | SMN1; SMN2NPC1RAB9AMAPTTP53 | |
| SCHEMBL6582896 | 0.77 | MAPT (0.47) | SMN1; SMN2NPC1RAB9AMAPTTP53 | |
| SCHEMBL5747211 | 0.77 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1RAB9AMAPTTP53 | |
| SCHEMBL4629906 | 0.75 | EPHX1 (0.38) | SMN1; SMN2NPC1RAB9AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1857453-B1 | FLUOROALKYLPYRROLIDINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2010-12-29 | — | — | EP | disclosed |
| US-20090012119-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | DAIICHI SANKYO COMPANY LIMITED (JP) | 2009-01-08 | — | — | US | disclosed |
| EP-1857453-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2007-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012119-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | FPR1, VIP, Q6ZSR9 | SMN1; SMN2 4468/4885NPC1 850/4885RAB9A 1384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.