Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | LOX | P28300 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2963101 | 0.79 | ALOX5 (0.50) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL6969326 | 0.75 | ALOX5 (0.43) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL28564145 | 0.73 | ALOX5 (0.42) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL477483 | 0.73 | HPGD (0.49) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL1444769 | 0.72 | ALOX5 (0.55) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL16018597 | 0.71 | ALOX5 (0.40) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL8306477 | 0.71 | ALOX5 (0.41) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL7691578 | 0.70 | CYP2A6 (0.53) | CYP2A6 | |
| SCHEMBL16018672 | 0.70 | ALOX5 (0.36) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL9824749 | 0.69 | ALOX5 (0.53) | ALOX5CYP1A2PTGESLMNALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340676-B2 | ANTIBIABETIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-22 | — | — | US | disclosed |
| US-20010020037-A1 | 4-aryl-1-oxa-9-thia-cyclopenta (b) fluorenes | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-09-06 | — | — | US | disclosed |
| US-6281238-B1 | USEFUL IN TREATING METABOLIC DISORDERS RELATED TO INSULIN RESISTANCE OR HYPERGLYCEMIA. | AMERICAN HOME PRODUCTS CORPORATION | 2001-08-28 | — | — | US | disclosed |
| US-6057316-A | 4-aryl-1-oxa-9-thia-cyclopenta[b]fluorenes | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010020037-A1 | 4-aryl-1-oxa-9-thia-cyclopenta (b) fluorenes | INSR, IRS1, IGF1R | ALOX5 2892/4885CYP1A2 195/4885PTGES 4283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.