Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 4/20 | 0.55 |
| ▸ | CA2 | P00918 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7696383 | 0.90 | DHFR (0.74) | DHFRKMT2AMEN1TP53CA1 | |
| SCHEMBL7701429 | 0.83 | TP53 (0.80) | DHFRKMT2AMEN1TP53CA1 | |
| SCHEMBL7692901 | 0.83 | ALDH1A1 (0.66) | DHFRKMT2ACA1CA2HTT | |
| SCHEMBL10144688 | 0.82 | EGFR (0.60) | DHFRKMT2ACA1CA2HTT | |
| SCHEMBL10961715 | 0.82 | KDM4E (0.62) | KMT2AMEN1TP53KDM4EHTT | |
| SCHEMBL10113461 | 0.81 | DHFR (0.64) | DHFRKMT2AMEN1CA1CA2 | |
| SCHEMBL13420163 | 0.80 | CA1 (0.77) | DHFRKMT2AMEN1CA1CA2 | |
| SCHEMBL11007706 | 0.79 | KDM4E (0.59) | KMT2AMEN1TP53KDM4EHTT | |
| SCHEMBL11008722 | 0.79 | KDM4E (0.57) | KMT2AMEN1TP53KDM4EHTT | |
| SCHEMBL5340104 | 0.78 | KMT2A (0.86) | KMT2AMEN1TP53KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002066443-A2 | 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-08-29 | — | — | WO | claimed |
| WO-2002066443-A2 | 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-08-29 | — | — | WO | disclosed |