Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | DHFR | P00374 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | CA1 | P00915 | 3/20 | 0.59 |
| ▸ | CA2 | P00918 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7696383 | 0.89 | DHFR (0.74) | TP53KMT2AMEN1DHFRALDH1A1 | |
| SCHEMBL7694652 | 0.83 | DHFR (0.63) | TP53KMT2AMEN1DHFRSMN1; SMN2 | |
| SCHEMBL14164070 | 0.81 | DHFR (0.79) | TP53DHFRSMN1; SMN2ALDH1A1CA1 | |
| SCHEMBL7691974 | 0.78 | CA1 (0.56) | TP53KMT2AMEN1DHFRSMN1; SMN2 | |
| SCHEMBL10113073 | 0.78 | CA1 (0.74) | KMT2AMEN1DHFRSMN1; SMN2ALDH1A1 | |
| SCHEMBL5340104 | 0.77 | KMT2A (0.86) | TP53KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7696472 | 0.77 | ALDH1A1 (0.54) | TP53KMT2AMEN1DHFRSMN1; SMN2 | |
| SCHEMBL31541594 | 0.76 | DHFR (0.67) | TP53KMT2AMEN1DHFRSMN1; SMN2 | |
| SCHEMBL26598049 | 0.75 | DHFR (0.66) | KMT2AMEN1DHFRSMN1; SMN2ALDH1A1 | |
| SCHEMBL14164069 | 0.75 | DHFR (0.66) | TP53DHFRSMN1; SMN2ALDH1A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002066443-A2 | 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-08-29 | — | — | WO | disclosed |