Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 8/20 | 0.44 |
| ▸ | CA9 | Q16790 | 5/20 | 0.44 |
| ▸ | CA1 | P00915 | 5/20 | 0.44 |
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | CA4 | P22748 | 2/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7159890 | 0.82 | GPR35 (0.54) | KMT2AMEN1ALDH1A1GPR35KDM4E | |
| SCHEMBL30678498 | 0.81 | F2 (0.45) | F2PRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL3974928 | 0.79 | SMN1; SMN2 (0.47) | F2PRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL7027335 | 0.79 | GPR35 (0.55) | KMT2AMEN1ALDH1A1GPR35KDM4E | |
| SCHEMBL31437144 | 0.78 | KMT2A (0.44) | F2PRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL29052405 | 0.78 | KMT2A (0.44) | F2PRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL1548597 | 0.78 | FBP1 (0.45) | F2PRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL4690711 | 0.78 | KMT2A (0.48) | F2PRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL7643805 | 0.78 | GPR35 (0.46) | KMT2AMEN1ALDH1A1LMNAGPR35 | |
| SCHEMBL3393735 | 0.78 | GPR35 (0.46) | KMT2AMEN1ALDH1A1GPR35MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002081466-A1 | PRODRUGS OF 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES | SUGEN, INC. (US) | 2002-10-17 | — | — | WO | disclosed |