Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4203714 | 0.98 | EGFR (0.53) | EGFRTTBK1TRPV1CNR1FLT3 | |
| SCHEMBL17815581 | 0.83 | EGFR (0.49) | EGFRTTBK1 | |
| SCHEMBL1896427 | 0.82 | TTBK1 (0.55) | EGFRTTBK1 | |
| SCHEMBL6033642 | 0.82 | DHODH (0.56) | EGFRTTBK1TRPV1CNR1FLT3 | |
| SCHEMBL17815587 | 0.80 | GALR3 (0.58) | EGFRTTBK1TRPV1 | |
| SCHEMBL6034099 | 0.79 | TRPV1 (0.47) | EGFRTTBK1TRPV1CNR1FLT3 | |
| SCHEMBL1898192 | 0.79 | EGFR (0.53) | EGFRTTBK1 | |
| SCHEMBL6473517 | 0.78 | CNR1 (0.48) | EGFRTTBK1TRPV1CNR1FLT3 | |
| SCHEMBL29438983 | 0.77 | EGFR (0.56) | EGFRTTBK1TRPV1CNR1FLT3 | |
| SCHEMBL6252004 | 0.76 | CA1 (0.65) | EGFRTTBK1TRPV1CNR1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160376291-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2016-12-29 | — | — | US | disclosed |
| US-9440978-B2 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2016-09-13 | — | — | US | disclosed |
| US-9440978-B2 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2016-09-13 | — | — | US | disclosed |
| EP-2224929-B1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2016-05-04 | — | — | EP | disclosed |
| US-20140107098-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | JANSSEN PHARMACEUTICA NV (US) | 2014-04-17 | — | — | US | disclosed |
| US-20140107098-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | JANSSEN PHARMACEUTICA NV (US) | 2014-04-17 | — | — | US | disclosed |
| EP-2398778-B1 | AMINOPYRIDINEAMIDES AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2014-03-26 | — | — | EP | disclosed |
| EP-2398778-B1 | AMINOPYRIDINEAMIDES AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2014-03-26 | — | — | EP | disclosed |
| US-8637527-B2 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-28 | — | — | US | disclosed |
| US-8637527-B2 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-28 | — | — | US | disclosed |
| US-20120071496-A1 | Aminopyrimidinamides As Pest Control Agents | BAYER CROPSCIENCE AG (DE) | 2012-03-22 | — | — | US | disclosed |
| EP-2398778-A1 | AMINOPYRIMIDINAMIDES AS PEST CONTROL AGENTS | Bayer CropScience AG (DE) | 2011-12-28 | — | — | EP | disclosed |
| US-20100298267-A1 | AMINOPYRIMIDINAMIDES AS PESTICIDES | BAYER CROPSCIENCE AG (US) | 2010-11-25 | — | — | US | disclosed |
| US-20100298267-A1 | AMINOPYRIMIDINAMIDES AS PESTICIDES | BAYER CROPSCIENCE AG (US) | 2010-11-25 | — | — | US | disclosed |
| US-20100298267-A1 | AMINOPYRIMIDINAMIDES AS PESTICIDES | BAYER CROPSCIENCE AG (US) | 2010-11-25 | — | — | US | disclosed |
| WO-2010094406-A1 | AMINOPYRIMIDINAMIDES AS PEST CONTROL AGENTS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2010-08-26 | — | — | WO | disclosed |
| WO-2010094406-A1 | AMINOPYRIMIDINAMIDES AS PEST CONTROL AGENTS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2010-08-26 | — | — | WO | disclosed |
| WO-2009078999-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-06-25 | — | — | WO | disclosed |
| US-20090156599-A1 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
| US-20090156599-A1 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298267-A1 | AMINOPYRIMIDINAMIDES AS PESTICIDES | DDT, NPEPPS, PTMS | EGFR 4629/4885TTBK1 2464/4885TRPV1 1493/4885 |
| US-20160376291-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | TRPV1, TRPA1, TRPV4 | EGFR 2036/4885TTBK1 1556/4885TRPV1 1/4885 |
| US-20140107098-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | TRPV1, TRPA1, TRPV4 | EGFR 2036/4885TTBK1 1556/4885TRPV1 1/4885 |
| US-20090156599-A1 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | TRPV1, TRPA1, TRPV4 | EGFR 2036/4885TTBK1 1556/4885TRPV1 1/4885 |
| US-20120071496-A1 | Aminopyrimidinamides As Pest Control Agents | NPEPPS, DDT, DNPEP | EGFR 4321/4885TTBK1 1824/4885TRPV1 2680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.