Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PORCN | Q9H237 | 3/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4317299 | 0.88 | SMN1; SMN2 (0.51) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL4322581 | 0.84 | RAB9A (0.54) | NPC1RAB9ASMN1; SMN2ALDH1A1PORCN | |
| Iodide SCHEMBL4312418 | 0.83 | RAB9A (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1PORCN | |
| SCHEMBL7696670 | 0.81 | TBXAS1 (0.38) | NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL4315611 | 0.78 | SMN1; SMN2 (0.42) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL4315680 | 0.77 | CYP11B1 (0.49) | NPC1CYP1A2 | |
| Hydrochloric Acid SCHEMBL4317167 | 0.76 | CYP11B1 (0.48) | CYP1A2 | |
| SCHEMBL6968837 | 0.75 | SMN1; SMN2 (0.58) | NPC1RAB9ASMN1; SMN2TP53HRH3 | |
| SCHEMBL9039593 | 0.74 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2TP53HRH3 | |
| Bromide SCHEMBL8180586 | 0.74 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2TP53HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6335445-B1 | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2002-01-01 | — | — | US | claimed |