Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | DHFR | P00374 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7691835 | 0.82 | ALDH1A1 (0.54) | LMNAGAADHFRALDH1A1CA1 | |
| SCHEMBL7691845 | 0.79 | LMNA (0.51) | LMNAGAADHFRALDH1A1CA1 | |
| SCHEMBL7693299 | 0.77 | SMN1; SMN2 (0.60) | LMNADHFRALDH1A1CA1CA2 | |
| SCHEMBL7696191 | 0.75 | LMNA (0.49) | LMNAGAADHFRALDH1A1CA1 | |
| SCHEMBL7688881 | 0.73 | DHFR (0.64) | LMNAGAADHFRALDH1A1CA1 | |
| SCHEMBL7693967 | 0.73 | DHFR (0.55) | LMNAGAADHFRALDH1A1CA1 | |
| SCHEMBL7690794 | 0.71 | DHFR (0.71) | DHFRALDH1A1CA1CA2ADORA2B | |
| SCHEMBL7695564 | 0.71 | ALDH1A1 (0.70) | LMNADHFRALDH1A1CA1CA2 | |
| SCHEMBL7697851 | 0.70 | DHFR (0.59) | LMNADHFRALDH1A1CA1CA2 | |
| SCHEMBL7691910 | 0.70 | DHFR (0.69) | LMNADHFRALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002066443-A2 | 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-08-29 | — | — | WO | disclosed |