SCHEMBL7697272

SCHEMBL7697272

Cc1noc(=O)n1CCCCOCc1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TEAD3 Q99594 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CYP1A2 P05177 2/20 0.39
CYP2D6 P10635 2/20 0.39
CYP2C19 P33261 2/20 0.39
ALDH1A1 P00352 2/20 0.39
CYP2C9 P11712 1/20 0.39
NR4A2 P43354 1/20 0.39
GBA1 P04062 3/20 0.38
UGCG Q16739 2/20 0.38
GBA2 Q9HCG7 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
MAPT P10636 1/20 0.38
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
TSHR P16473 1/20 0.37
NAAA Q02083 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3524552 0.72 MAOA (0.45) TEAD3L3MBTL1ALDH1A1MEN1KMT2A
SCHEMBL2640223 0.70 TSHR (0.70) TDP1L3MBTL1GBA1UGCGGBA2
SCHEMBL7693172 0.70 TSHR (0.38) TDP1ALDH1A1MEN1KMT2AMAPT
SCHEMBL7586172 0.68 ALDH1A1 (0.46) TEAD3TDP1L3MBTL1CYP1A2CYP2D6
SCHEMBL6597617 0.68 MEN1 (0.41) TEAD3TDP1L3MBTL1CYP1A2CYP2D6
SCHEMBL9011624 0.68 TSHR (0.67) TDP1L3MBTL1GBA1UGCGGBA2
SCHEMBL9011734 0.68 TSHR (0.67) TDP1L3MBTL1GBA1UGCGGBA2
SCHEMBL9011715 0.68 TSHR (0.67) TDP1L3MBTL1GBA1UGCGGBA2
SCHEMBL9011646 0.68 TSHR (0.67) TDP1L3MBTL1GBA1UGCGGBA2
SCHEMBL9011595 0.68 TSHR (0.67) TDP1L3MBTL1GBA1UGCGGBA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6344473-B1 NITRIC OXIDE SYNTHASE INHIBITOR G.D. SEARLE & CO. 2002-02-05 US disclosed
US-6136829-A NITRIC OXIDE SYNTHETASE INHIBITORS G.D. SEARLE & CO. (US) 2000-10-24 US disclosed
US-5981556-A USEFUL IN TREATMENT OF INFLAMMATORY CONDITIONS AFFECTING THE JOINTS, FOR EXAMPLE ARTHRITIS, AND ALSO INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, MIGRAINE G.D. SEARLE & CO. (US) 1999-11-09 US disclosed
US-5958958-A ANTIINFLAMMATORY AGENT; HYPOTENSIVE AGENT G.D. SEARLE & CO. (US) 1999-09-28 US disclosed