Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | RGS12 | O14924 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.30 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12284083 | 0.89 | ALDH1A1 (0.34) | MAPTKMT2AALDH1A1HTT | |
| SCHEMBL14446910 | 0.87 | HSD17B10 (0.40) | TSHRMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL10388579 | 0.70 | MAPT (0.41) | TSHRMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL7697272 | 0.70 | TEAD3 (0.39) | TSHRMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL2032325 | 0.67 | ALDH1A1 (0.43) | TSHRMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL25465030 | 0.65 | ALDH1A1 (0.42) | TSHRMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL13327050 | 0.65 | ALDH1A1 (0.42) | TSHRMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL9263752 | 0.63 | MAPT (0.47) | TSHRMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL12060391 | 0.63 | HTT (0.38) | MAPTKMT2AKDM4EMEN1RGS12 | |
| SCHEMBL9460144 | 0.60 | MAPT (0.48) | TSHRMAPTKMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344473-B1 | NITRIC OXIDE SYNTHASE INHIBITOR | G.D. SEARLE & CO. | 2002-02-05 | — | — | US | disclosed |
| US-6136829-A | NITRIC OXIDE SYNTHETASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-10-24 | — | — | US | disclosed |
| US-5981556-A | USEFUL IN TREATMENT OF INFLAMMATORY CONDITIONS AFFECTING THE JOINTS, FOR EXAMPLE ARTHRITIS, AND ALSO INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, MIGRAINE | G.D. SEARLE & CO. (US) | 1999-11-09 | — | — | US | disclosed |
| US-5958958-A | ANTIINFLAMMATORY AGENT; HYPOTENSIVE AGENT | G.D. SEARLE & CO. (US) | 1999-09-28 | — | — | US | disclosed |