Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.64 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.64 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | UBE2M | P61081 | 1/20 | 0.46 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3616171 | 0.75 | HDAC1 (0.50) | SIGMAR1HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL7699455 | 0.75 | SIGMAR1 (0.69) | SIGMAR1GRIN1GRIN2B | |
| SCHEMBL13718720 | 0.74 | ALDH1A1 (0.52) | SIGMAR1GRIN1GRIN2BKDM4ECRHBP | |
| SCHEMBL1634482 | 0.74 | ALDH1A1 (0.52) | SIGMAR1GRIN1GRIN2BKDM4ECRHBP | |
| SCHEMBL191727 | 0.73 | HTT (0.60) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL191726 | 0.73 | HTT (0.60) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL3421659 | 0.73 | HTT (0.60) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL20183285 | 0.72 | DRD4 (0.70) | SIGMAR1 | |
| SCHEMBL19614234 | 0.72 | DRD4 (0.70) | SIGMAR1 | |
| SCHEMBL17961749 | 0.72 | DRD4 (0.70) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002057258-A1 | CYCLO`D!AZEPANE DERIVATIVES WHICH ARE USED AS FARNESYLTRANSFERASE INHIBITORS AND METHOD FOR THE PREPARATION THEREOF | LES LABORATOIRES SERVIER (FR) | 2002-07-25 | — | — | WO | disclosed |