Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.61 |
| ▸ | PPARA | Q07869 | 8/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11838433 | 0.94 | PPARG (0.66) | PPARGPPARAHRH3SIGMAR1KCNA5 | |
| SCHEMBL11842801 | 0.85 | PPARG (0.60) | PPARGPPARADRD2SIGMAR1KCNA5 | |
| SCHEMBL11835059 | 0.84 | PPARG (0.61) | PPARGPPARASIGMAR1S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL11843021 | 0.84 | PPARG (0.60) | PPARGPPARASIGMAR1S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL11834805 | 0.83 | PPARG (0.63) | PPARGPPARAHRH3KCNA5 | |
| SCHEMBL28058024 | 0.74 | SIGMAR1 (0.58) | PPARGPPARADRD2SIGMAR1HTR1A | |
| Hydrochloric Acid SCHEMBL11832653 | 0.74 | PPARG (0.61) | PPARGPPARASIGMAR1KCNA5S1PR1 | |
| SCHEMBL9531074 | 0.74 | SIGMAR1 (0.74) | PPARGPPARADRD2SIGMAR1HTR1A | |
| SCHEMBL7702261 | 0.73 | PPARG (0.51) | PPARGPPARADRD2SIGMAR1S1PR1 | |
| Hydrochloric Acid SCHEMBL11842023 | 0.73 | PPARG (0.60) | PPARGPPARAHRH3SIGMAR1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885004-B1 | USE OF 4-PHENYL-3,6-DIHYDRO-2H-PYRIDYL DERIVATIVES AS NMDA RECEPTOR SUBTYPE BLOCKERS | HOFFMANN LA ROCHE (CH) | 2002-05-02 | — | — | EP | claimed |
| EP-0885004-A1 | USE OF 4-PHENYL-3,6-DIHYDRO-2H-PYRIDYL DERIVATIVES AS NMDA RECEPTOR SUBTYPE BLOCKERS | F.HOFFMANN-LA ROCHE AG (CH) | 1998-12-23 | — | — | EP | claimed |
| WO-1997032581-A1 | USE OF 4-PHENYL-3,6-DIHYDRO-2H-PYRIDYL DERIVATIVES AS NMDA RECEPTOR SUBTYPE BLOCKERS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-12 | — | — | WO | claimed |
| EP-0885004-B1 | USE OF 4-PHENYL-3,6-DIHYDRO-2H-PYRIDYL DERIVATIVES AS NMDA RECEPTOR SUBTYPE BLOCKERS | HOFFMANN LA ROCHE (CH) | 2002-05-02 | — | — | EP | disclosed |
| EP-0885004-A1 | USE OF 4-PHENYL-3,6-DIHYDRO-2H-PYRIDYL DERIVATIVES AS NMDA RECEPTOR SUBTYPE BLOCKERS | F.HOFFMANN-LA ROCHE AG (CH) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032581-A1 | USE OF 4-PHENYL-3,6-DIHYDRO-2H-PYRIDYL DERIVATIVES AS NMDA RECEPTOR SUBTYPE BLOCKERS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-12 | — | — | WO | disclosed |