Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | HTR7 | P34969 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133832 | 0.81 | CCR2 (0.66) | ADRA1D | |
| SCHEMBL11995164 | 0.78 | ADRA1D (0.53) | ADRA1DHTR2AHTR7DRD2KCNH2 | |
| SCHEMBL11995186 | 0.77 | ADRA1D (0.56) | ADRA1DHTR2AHTR7DRD2KCNH2 | |
| SCHEMBL7700873 | 0.76 | ADRA1D (0.65) | ADRA1DDRD2DRD4DRD3 | |
| SCHEMBL11995191 | 0.76 | CYP2D6 (0.56) | ADRA1DHTR2AHTR7DRD2KCNH2 | |
| SCHEMBL557776 | 0.75 | KDM4E (0.70) | CHRM4ADRA1DKDM4EBRD4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1703924 | 0.74 | KDM4E (0.68) | CHRM4ADRA1DKDM4EBRD4ALDH1A1 | |
| SCHEMBL14306777 | 0.74 | ADRA1D (0.80) | ADRA1DKDM4E | |
| SCHEMBL27887336 | 0.73 | HTR2A (0.52) | ADRA1DHTR2AHTR7DRD2KCNH2 | |
| SCHEMBL373860 | 0.73 | KDM4E (0.60) | ADRA1DHTR2AHTR7DRD2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002079190-A1 | 3-SUBSTITUTED INDOLES AS CHEMOKINE ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-10-10 | — | — | WO | disclosed |