Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 14/20 | 0.50 |
| ▸ | MMP1 | P03956 | 14/20 | 0.50 |
| ▸ | MMP9 | P14780 | 12/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928756 | 0.87 | MMP13 (0.57) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL6928876 | 0.82 | MMP13 (0.47) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL6928552 | 0.79 | MMP1 (0.54) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL7624918 | 0.78 | MMP13 (0.49) | MMP13MMP1MMP9ADAM17LMNA | |
| SCHEMBL6932240 | 0.77 | MMP1 (0.69) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL6932195 | 0.77 | MMP13 (0.63) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL6935154 | 0.75 | MMP9 (0.77) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL6929880 | 0.75 | MMP1 (0.76) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL6932184 | 0.74 | MMP1 (0.62) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL6934097 | 0.73 | MMP9 (0.75) | MMP13MMP1MMP9ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6342508-B1 | ENZYME INHIBITORS FOR PROTECTION OF CONNECTIVE TISSUES | AMERICAN CYANAMID COMPANY | 2002-01-29 | — | — | US | disclosed |