Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 1/20 | 0.55 |
| ▸ | CHRNG | P07510 | 1/20 | 0.55 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.55 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.55 |
| ▸ | CHRND | Q07001 | 1/20 | 0.55 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.38 |
| ▸ | FASN | P49327 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4409738 | 0.80 | KDM4E (0.50) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL15544942 | 0.76 | USP30 (0.54) | ALDH1A1USP30FASN | |
| SCHEMBL7694165 | 0.75 | CHRNB2 (0.61) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL6824751 | 0.74 | CHRNB2 (0.58) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL5769083 | 0.72 | GPR119 (0.49) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL16905570 | 0.71 | CHRNA1 (0.65) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL4412259 | 0.71 | CHRNB2 (1.00) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL16905238 | 0.71 | CHRNA1 (0.59) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL16905466 | 0.71 | CHRNA1 (0.64) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL2225020 | 0.71 | USP30 (0.59) | PTGDR2ALDH1A1USP30FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020072525-A1 | Aryl fused azapolycyclic compounds | PFIZER INC | 2002-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020072525-A1 | Aryl fused azapolycyclic compounds | GRIN2C, GRIN2A, GRIN2B | CHRNA1 375/4885CHRNG 1914/4885CHRNB1 665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.